Stimulating Nerve Growth Factor (NGF)

Nerve growth factor (NGF) is the first discovered member of the neurotrophin family[1]. NGF is essential for the development and phenotypic maintenance of neurons in the peripheral nervous system (PNS) and for the functional integrity of cholinergic neurons in the central nervous system (CNS) [2]. The amino acid and messenger RNA sequences of this neurotrophin have been classified and indicate that NGF is a highly conserved molecule that shares considerable homology within different species[3]. The mature, active form of NGF descend from proteolitic cleavage of a precursor form (ProNGF), that have important roles during development and in adult life, having both pro-apoptotic and neurotrophic properties

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